Mechanisms linking hyperglycemia in pregnancy to the offspring cardiovascular system dysfunction

Hyperglycemia in pregnancy (HIP) is a high-glycemic state that occurs during pregnancy, and gestational diabetes mellitus (GDM) the major cause of it. Studies reveal GDM has long-term adverse impacts on mothers offspring, such as maternal type 2 diabetes, premature birth stillbirth newborns, cardiovascular disease, metabolic disorders adult offspring. In recent years, studies transcription level metabonomics have provided new insights into pathophysiological mechanism GDM. This article reviews transcriptional levels metabolomics involving dysfunction which may provide insight to health pregnant women